Phaseollin
13401-40-6
Product Name: Phaseolin
Appearance: White powder
Source: White kidney beans
CAS number 13401-40-6
Molecular weight 322.354
Molecular formula C20H18O4
Appearance: White powder
Source: White kidney beans
CAS number 13401-40-6
Molecular weight 322.354
Molecular formula C20H18O4
Product Name | Phaseolin | |||
Appearance | White crystalline powder | |||
Specification | 1%-5% | |||
Test Method | HPLC | |||
Storage | Keep in a cool, dry, dark location in a tightly sealed container or cylinder. | |||
Shelf Time | 24 months | |||
Phaseollin is a secondary metabolite of brassica beans induced by external stimuli (biotic and abiotic factors) and is a phytodefensin. The molecular formula is C20H18O4 and the molecular weight is 322.4. It has various pharmacological activities, such as inhibition of α-amylase, estrogenic activity, and potential antitumor effects. However, it has been shown that brassica beans do not produce cauliflowerin in the absence of external stress or exogenous stimuli.
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1,Inhibition of α-amylase
Phaseollincan inhibition of alpha-amylase. Many plants produce α-amylase inhibitors that ward off insects and protect the plant. These inhibitors fall into three types. Cauliflowerin was one of the first of these to be isolated in the 1970s. It is a protein that is associated with a sugar called Glycoprotein. This alpha-amylase inhibitor is effective against animal alpha-amylases, but has no effect on the corresponding microbial or plant enzymes.
2,Estrogenic activity
Stephen et al. (2011) applied Aspergillus sojae as an inducer to induce the production of cauliflowerin from red kidney beans, and detected its effect on the proliferation of Mcf-7 cells and HEek-293 cells by ERE luciferase, and proved that cauliflowerin has estrogenic activity through the analysis of binding affinity with estrogen receptor (ER) and can be used as a functional food ingredient for research and development.
3,Potential anti-tumour activity
Wätjen et al. (2007) isolated two zitanoid flavonoids from Erythrina addisoniae, phaseollin and neorautenol, which inhibited the growth of hepatocellular carcinoma cells H4IIE, and both were able to reduce ERK kinase activity, a mitogen-activated protein kinase that is associated with cell growth. activated protein kinase that is associated with cell proliferation.
Phaseollincan inhibition of alpha-amylase. Many plants produce α-amylase inhibitors that ward off insects and protect the plant. These inhibitors fall into three types. Cauliflowerin was one of the first of these to be isolated in the 1970s. It is a protein that is associated with a sugar called Glycoprotein. This alpha-amylase inhibitor is effective against animal alpha-amylases, but has no effect on the corresponding microbial or plant enzymes.
2,Estrogenic activity
Stephen et al. (2011) applied Aspergillus sojae as an inducer to induce the production of cauliflowerin from red kidney beans, and detected its effect on the proliferation of Mcf-7 cells and HEek-293 cells by ERE luciferase, and proved that cauliflowerin has estrogenic activity through the analysis of binding affinity with estrogen receptor (ER) and can be used as a functional food ingredient for research and development.
3,Potential anti-tumour activity
Wätjen et al. (2007) isolated two zitanoid flavonoids from Erythrina addisoniae, phaseollin and neorautenol, which inhibited the growth of hepatocellular carcinoma cells H4IIE, and both were able to reduce ERK kinase activity, a mitogen-activated protein kinase that is associated with cell growth. activated protein kinase that is associated with cell proliferation.
1. Use in Dietary Supplements
- Weight Management: Phaseolin's ability to inhibit α-amylase makes it a popular ingredient in weight management supplements. By inhibiting the enzyme that breaks down starch, Phaseolin can potentially reduce the absorption of carbohydrates from the diet, thereby aiding in weight loss or weight maintenance.
- Blood Sugar Control: For individuals with diabetes or those seeking to manage their blood sugar levels, Phaseolin may also be beneficial. By reducing the breakdown and absorption of starch, it can help lower postprandial (after-meal) blood sugar levels.
2. Food Industry Applications
- Functional Foods: Phaseolin can be incorporated into functional foods that are designed to provide specific health benefits beyond basic nutrition. These foods may be targeted at consumers looking to manage their weight, blood sugar, or other health concerns.
- Food Additives: Due to its emulsifying and stabilizing properties, Phaseolin can also be used as a food additive to improve the texture, stability, and shelf life of various food products.
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