Luteolin

Basic Information

• Chemical Name: 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
• CAS Number: 491-70-3
• Molecular Formula: C15H10O6
• Molecular Weight: 286.24
• Appearance: Yellow powder
• Solubility: Soluble in ethanol and ether; slightly soluble in hot water; insoluble in cold water

Natural Sources

Luteolin is widely distributed in nature and can be found in various plants, including:

• Leaves, rinds, barks, clover blossom, and ragweed pollen
• Vegetables and fruits such as celery, broccoli, green pepper, parsley, thyme, dandelion, chamomile, carrots, and oranges
• Other plants such as olive oil, peppermint, rosemary, and orega

1. Antioxidant and Anti-inflammatory Properties:

   • Luteolin scavenges free radicals and inhibits oxidative stress, thereby protecting cells and tissues from damage.
   • It also reduces inflammation by inhibiting the production of inflammatory mediators.

2. Antitumor Activity:

   • Luteolin has been shown to exhibit antitumor properties by inhibiting the growth and proliferation of cancer cells.
   • It can induce cell apoptosis and cell cycle arrest, as well as inhibit metastasis and angiogenesis in cancer cells.

3. Antimicrobial and Antiviral Effects:

   • Luteolin has broad-spectrum antimicrobial activity against bacteria, fungi, and viruses.
   • It can inhibit the replication and spread of viruses, including SARS and HIV, by inhibiting the activity of viral proteins.

4. Neuroprotective Effects:

   • Luteolin affects the central nervous system by acting as a positive allosteric modulator of the GABAA receptor.
   • It has been found to improve memory efficacy and may have potential applications in the treatment of neurological disorders.

5. Other Benefits:

   • Luteolin has been reported to have anti-allergic, anticoagulant, and anti-hyperuric acid properties.
   • It may also be useful in the treatment of cardiovascular diseases, respiratory diseases such as COPD and bronchial asthma, as well as chronic cough caused by chronic pharyngitis and allergic rhinitis.

1. Pharmaceutical Industry:

   • As an active ingredient in drugs for the treatment of cancer, inflammation, infection, and neurological disorders.

2. Cosmetic Industry:

   • As an antioxidant and anti-inflammatory agent in skincare products to improve skin health and reduce aging signs.

3. Food Industry:

   • As a natural preservative and antioxidant to extend the shelf life of foods and enhance their nutritional value.

4. Nutritional Supplements:

   • As a dietary supplement to provide antioxidant and anti-inflammatory benefits and support overall health.