Berberine hydrochloride
633-65-8
Product Name: Berberine Hydrochloride
appearance; Yellow powder
Source: Coptis chinensis Franch
CAS number 633-65-8
Molecular weight 372.822
Molecular formula C20H18ClNO4
appearance; Yellow powder
Source: Coptis chinensis Franch
CAS number 633-65-8
Molecular weight 372.822
Molecular formula C20H18ClNO4
Product Name | Berberine Hydrochloride | |||
Appearance | Yellow powder | |||
Specification | 98% | |||
Test Method | HPLC | |||
Storage | Keep in a cool, dry, dark location in a tightly sealed container or cylinder. | |||
Shelf Time | 24 months | |||
Berberine Hydrochloride, also known as berberine, is a type of isoquinoline alkaloid extracted from plants such as Coptis chinensis, Phellodendron amurense, and Berberis. Here's a detailed overview of Berberine Hydrochloride:
Basic Information
- CAS Number: 633-65-8
- Molecular Formula: C20H18NO4·HCl
- Molecular Weight: 371.81
- Appearance: Yellow powder
- Melting Point: 204-206°C
- Solubility: Soluble in methanol, slightly soluble in cold water, and easily soluble in hot water. It is insoluble in ethanol, chloroform, and ether.
Extraction and Occurrence
Berberine Hydrochloride is naturally occurring in the roots and stems of certain plants, primarily in the Berberidaceae family. It can be extracted through various chemical processes involving the use of acids like sulfuric acid followed by precipitation with hydrochloric acid to obtain the hydrochloride salt.
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- Antibacterial Activity: Berberine Hydrochloride has inhibitory effects on a wide range of bacteria, including Escherichia coli, Shigella, Staphylococcus aureus, Streptococcus pneumoniae, Salmonella typhimurium, and other Gram-positive and Gram-negative bacteria. It is particularly effective in treating bacterial diarrhea, such as that caused by Shigella.
- Anti-inflammatory and Antioxidant Effects: Berberine exhibits anti-inflammatory and antioxidant properties, which contribute to its efficacy in treating gastrointestinal inflammation and other inflammatory conditions.
- Blood Sugar and Lipid Regulation: Berberine has been shown to improve insulin sensitivity and lower blood sugar levels, making it a useful adjunct in the management of diabetes. It also has favorable effects on lipid metabolism, reducing triglyceride and cholesterol levels.
- Anti-atherosclerosis: Berberine can prevent the formation of atherosclerotic plaques by inhibiting the proliferation and migration of vascular smooth muscle cells and reducing the accumulation of lipids in the vessel wall.
- Anti-arrhythmic Effects: Berberine has been found to have anti-arrhythmic properties, which can help regulate heart rate and rhythm.
- Anti-tumor Activity: Berberine demonstrates antitumor activity both in vitro and in vivo, and can induce the differentiation of certain cancer cells.
- Antiviral Activity: Berberine has also shown inhibitory effects on some viruses, such as influenza virus.
Berberine Hydrochloride is widely used in clinical settings for the treatment of gastrointestinal infections, diarrhea, and other conditions. It is also used as an adjunct in the management of diabetes and hyperlipidemia due to its blood sugar- and lipid-lowering effects. Additionally, its anti-inflammatory, antioxidant, and antitumor properties make it a promising candidate for the treatment of various other diseases.
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