Cladribine
4291-63-8
Product Name: Cladribine
Product Code: HWSWKLQB
Specification: 99%
Certifications：ISO,GMP
Product grade:USP
Delivery：Shipped on the same day from stocks
MOQ：1KG
Product Code: HWSWKLQB
Specification: 99%
Certifications：ISO,GMP
Product grade:USP
Delivery：Shipped on the same day from stocks
MOQ：1KG
Product Name | Cladribine | |||
Appearance | White powder | |||
Specification | 99% | |||
Test Method | HPLC | |||
Storage | Keep in a cool, dry, dark location in a tightly sealed container or cylinder. | |||
Shelf Time | 24 months | |||
Xi'an Huawave Biotech Co., Ltd. is a professional Cladribine manufacturer and Cladribine supplier . We are committed to providing customers with professional research and development, production and sales, as well as OEM and ODM processing services.
1、 Main therapeutic effects
1、 Main therapeutic effects
Treat blood diseases
Leukemia: Cladribine can be used to treat hairy cell leukemia (HCL), especially in cases of clinically significant anemia, neutropenia, thrombocytopenia, and disease-related symptoms that occur after interferon treatment failure.
Neutropenia: Cladribine has therapeutic effects on neutropenia by affecting the body's hematopoietic function.
Anemia: For severe anemia caused by malnutrition, clarithromycin can stimulate the differentiation and maturation of hematopoietic stem cells, increase white blood cell count and other blood indicators, thereby improving anemia symptoms.
Anti-cancer effect
Cladribine can specifically recognize and kill cancer cells, exerting anti-cancer effects by interfering with their division and proliferation processes.
2、 Immune regulation and antiviral effects
Immune regulatory effect
Cladribine plays an immunomodulatory role by promoting lymphocyte maturation and affecting the body's immune response. This helps to enhance the patient's immune function and improve resistance.
Antiviral effect
Cladribine can interfere with viral DNA synthesis, block its replication process, and thus exert antiviral effects. This is of great significance for the treatment of certain viral infections.
3、 Other functions
Inhibit T cell proliferation
Cladribine can specifically bind to T cell surface receptors, inhibiting T cell activation and proliferation. This may have potential value for the treatment of certain autoimmune diseases.
Inhibition of macroglobulinemia
Cladribine can competitively inhibit Bcl-2 protein, induce apoptosis in macroglobulinemia cells, and reduce abnormally increased levels of immunoglobulin in the blood. This has positive implications for the treatment of immune related diseases such as macroglobulinemia.
Improve hematological parameters
Cladribine can improve hematological parameters in patients by stimulating hematopoietic function, increasing white blood cell count and other blood indicators.
Promote wound healing
Cladribine can enhance macrophage activity, accelerate the clearance of necrotic tissue and repair of new tissue, thereby helping to promote wound healing.
Cladribine is a drug used to treat specific types of cancer and immune disorders. The following are the main uses of Cladribine:
1、 Cancer treatment
Hairy Cell Leukemia (HCL):
Cladribine is a first-line treatment for hairy cell leukemia, particularly suitable for patients who have failed or cannot tolerate interferon therapy.
It interferes with the DNA synthesis and replication of cancer cells, leading to cancer cell death, thereby reducing disease symptoms and prolonging survival.
Other types of leukemia and lymphoma:
Cladribine is also used for the treatment of certain types of chronic lymphocytic leukemia (CLL) and other lymphomas, but is typically used as a second-line or third line treatment drug.
In these cases, it may be used in combination with other chemotherapy drugs to improve treatment efficacy.
2、 Immune disease treatment
Multiple Sclerosis (MS):
Oral formulations of Cladribine, such as Mavenclad, have been approved for the treatment of recurrent multiple sclerosis.
It improves patients' symptoms and quality of life by reducing excessive immune system activity, inflammation, and nerve damage.
Other autoimmune diseases:
Although Cladribine is mainly used for the treatment of multiple sclerosis, its immunomodulatory effects also make it potentially valuable in the treatment of other autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, etc.
However, these applications are still in the research stage and have not yet gained widespread clinical application.
3、 Precautions
The use of Cladribine requires strict adherence to the doctor's guidance, as it may lead to serious side effects, including infection, bone marrow suppression, liver dysfunction, etc.
Before using Cladribine, patients should undergo a comprehensive medical evaluation to ensure their suitability for treatment with the drug.
During treatment, patients should undergo regular blood tests and other necessary monitoring to evaluate the efficacy and safety of the medication.
Hairy Cell Leukemia (HCL):
Cladribine is a first-line treatment for hairy cell leukemia, particularly suitable for patients who have failed or cannot tolerate interferon therapy.
It interferes with the DNA synthesis and replication of cancer cells, leading to cancer cell death, thereby reducing disease symptoms and prolonging survival.
Other types of leukemia and lymphoma:
Cladribine is also used for the treatment of certain types of chronic lymphocytic leukemia (CLL) and other lymphomas, but is typically used as a second-line or third line treatment drug.
In these cases, it may be used in combination with other chemotherapy drugs to improve treatment efficacy.
2、 Immune disease treatment
Multiple Sclerosis (MS):
Oral formulations of Cladribine, such as Mavenclad, have been approved for the treatment of recurrent multiple sclerosis.
It improves patients' symptoms and quality of life by reducing excessive immune system activity, inflammation, and nerve damage.
Other autoimmune diseases:
Although Cladribine is mainly used for the treatment of multiple sclerosis, its immunomodulatory effects also make it potentially valuable in the treatment of other autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, etc.
However, these applications are still in the research stage and have not yet gained widespread clinical application.
3、 Precautions
The use of Cladribine requires strict adherence to the doctor's guidance, as it may lead to serious side effects, including infection, bone marrow suppression, liver dysfunction, etc.
Before using Cladribine, patients should undergo a comprehensive medical evaluation to ensure their suitability for treatment with the drug.
During treatment, patients should undergo regular blood tests and other necessary monitoring to evaluate the efficacy and safety of the medication.
You may also like