Eplerenone
107724-20-9
Product Name: Eplerenone
Product Code: HWSWYPLT
Specification: 99%
Certifications：ISO,GMP
Product grade:USP
Delivery：Shipped on the same day from stocks
MOQ：1KG
Product Code: HWSWYPLT
Specification: 99%
Certifications：ISO,GMP
Product grade:USP
Delivery：Shipped on the same day from stocks
MOQ：1KG
Product Name | Eplerenone | |||
Appearance | White powder | |||
Specification | 99% | |||
Test Method | HPLC | |||
Storage | Keep in a cool, dry, dark location in a tightly sealed container or cylinder. | |||
Shelf Time | 24 months | |||
Xi'an Huawave Biotech Co., Ltd. is a professional Eplerenone manufacturer and Eplerenone supplier . We are committed to providing customers with professional research and development, production and sales, as well as OEM and ODM processing services.
Eplerenone is an ACE inhibitor primarily used for the treatment of hypertension, heart failure, and post myocardial infarction rehabilitation. Its main function is to inhibit angiotensin-converting enzyme, block the process of converting angiotensin into angiotensin II, thereby reducing the level of angiotensin II, reducing vascular spasm and blood volume, dilating blood vessels, and lowering blood pressure. In addition, Eplerenone can promote the expansion of endothelial cells, increase the synthesis of nitrogen oxides, improve vascular function, and reduce the occurrence of cardiovascular events. Meanwhile, Eplerenone can also alleviate myocardial injury and remodeling, improve left ventricular systolic function, and prevent the occurrence and development of heart disease.
Eplerenone is an ACE inhibitor primarily used for the treatment of hypertension, heart failure, and post myocardial infarction rehabilitation. Its main function is to inhibit angiotensin-converting enzyme, block the process of converting angiotensin into angiotensin II, thereby reducing the level of angiotensin II, reducing vascular spasm and blood volume, dilating blood vessels, and lowering blood pressure. In addition, Eplerenone can promote the expansion of endothelial cells, increase the synthesis of nitrogen oxides, improve vascular function, and reduce the occurrence of cardiovascular events. Meanwhile, Eplerenone can also alleviate myocardial injury and remodeling, improve left ventricular systolic function, and prevent the occurrence and development of heart disease.
Eplerenone is a novel selective aldosterone receptor blocker with multiple medical applications. The following is a detailed summary of its uses:
1、 Main purpose
Treating heart failure
Eplerenone can be used to treat heart failure after myocardial infarction, especially for improving the survival rate of stable patients with symptomatic heart failure and reduced ejection fraction (≤ 40%) after acute myocardial infarction.
By inhibiting the action of aldosterone, eplerenone can reduce cardiac burden, improve cardiac function, and thus enhance the quality of life of patients.
Treating hypertension
Eplerenone can be used for the treatment of primary hypertension, and its antihypertensive effect is definite, especially for the significant decrease in systolic blood pressure.
For severe hypertension that cannot be controlled by the combination of multiple antihypertensive drugs, the addition of eplerenone can significantly lower blood pressure.
Iprenone can be used alone or in combination with other antihypertensive drugs to enhance its antihypertensive effect.
2、 Other functions
Protecting the kidneys
Eplerenone can significantly reduce glomerular ultrafiltration, decrease albuminuria in hypertensive patients, and have a protective effect on the kidneys.
For hypertensive patients with diabetes, this renal protective effect of epridone is more obvious.
Improve microalbuminuria in patients with diabetes
Eplerenone can improve the condition of microalbuminuria in patients with type II diabetes and help to alleviate the damage of diabetes to the kidney.
3、 Medication precautions
Usage and dosage
When treating heart failure, the commonly used dosage for adults starts at 25mg/d once daily and gradually adjusts to 50mg/d once daily. It is best to adjust the dosage within 4 weeks when the patient can tolerate it.
When treating hypertension, the recommended starting dose for adults is 50mg once daily. If the blood pressure lowering effect is not significant, it can be increased to 50mg twice a day. Do not recommend higher dosages of medication to avoid increasing the risk of adverse reactions such as hyperkalemia.
contraindication
Patients with hyperkalemia, type 2 diabetes patients with microalbuminuria, high serum creatinine level, and creatinine clearance rate less than 50mL/min should not take eplerenone.
Eplerenone should not be used in combination with potassium supplements, potassium salts, or contraindicated drugs (such as potassium sparing diuretics, CYP450 liver enzyme inhibitors).
Adverse reactions
Eplerenone has fewer adverse reactions and is well tolerated. Common adverse reactions include hyperkalemia, headache, dizziness, etc. If serious adverse reactions occur, seek medical attention promptly.
To sum up, Eplerenone has many medical purposes such as treating heart failure and hypertension, and can also protect the kidney and improve the microalbuminuria of diabetes patients. During the medication process, it is necessary to strictly follow the doctor's advice, pay attention to the usage, dosage, and contraindications to ensure the safety and effectiveness of the medication.
Treating heart failure
Eplerenone can be used to treat heart failure after myocardial infarction, especially for improving the survival rate of stable patients with symptomatic heart failure and reduced ejection fraction (≤ 40%) after acute myocardial infarction.
By inhibiting the action of aldosterone, eplerenone can reduce cardiac burden, improve cardiac function, and thus enhance the quality of life of patients.
Treating hypertension
Eplerenone can be used for the treatment of primary hypertension, and its antihypertensive effect is definite, especially for the significant decrease in systolic blood pressure.
For severe hypertension that cannot be controlled by the combination of multiple antihypertensive drugs, the addition of eplerenone can significantly lower blood pressure.
Iprenone can be used alone or in combination with other antihypertensive drugs to enhance its antihypertensive effect.
2、 Other functions
Protecting the kidneys
Eplerenone can significantly reduce glomerular ultrafiltration, decrease albuminuria in hypertensive patients, and have a protective effect on the kidneys.
For hypertensive patients with diabetes, this renal protective effect of epridone is more obvious.
Improve microalbuminuria in patients with diabetes
Eplerenone can improve the condition of microalbuminuria in patients with type II diabetes and help to alleviate the damage of diabetes to the kidney.
3、 Medication precautions
Usage and dosage
When treating heart failure, the commonly used dosage for adults starts at 25mg/d once daily and gradually adjusts to 50mg/d once daily. It is best to adjust the dosage within 4 weeks when the patient can tolerate it.
When treating hypertension, the recommended starting dose for adults is 50mg once daily. If the blood pressure lowering effect is not significant, it can be increased to 50mg twice a day. Do not recommend higher dosages of medication to avoid increasing the risk of adverse reactions such as hyperkalemia.
contraindication
Patients with hyperkalemia, type 2 diabetes patients with microalbuminuria, high serum creatinine level, and creatinine clearance rate less than 50mL/min should not take eplerenone.
Eplerenone should not be used in combination with potassium supplements, potassium salts, or contraindicated drugs (such as potassium sparing diuretics, CYP450 liver enzyme inhibitors).
Adverse reactions
Eplerenone has fewer adverse reactions and is well tolerated. Common adverse reactions include hyperkalemia, headache, dizziness, etc. If serious adverse reactions occur, seek medical attention promptly.
To sum up, Eplerenone has many medical purposes such as treating heart failure and hypertension, and can also protect the kidney and improve the microalbuminuria of diabetes patients. During the medication process, it is necessary to strictly follow the doctor's advice, pay attention to the usage, dosage, and contraindications to ensure the safety and effectiveness of the medication.
You may also like